Best Endpoint Detection and Response Software for Small Businesses (Free & Paid)

Running a small business comes with unique challenges, including tight budgets and limited resources. That’s why choosing the right endpoint detection and response software can significantly improve your workflow and help you compete more effectively. Here, we feature the top endpoint detection and response software solutions designed for small businesses—offering affordable pricing, user-friendly interfaces, and scalable features that grow alongside your company.

Last Updated: September 17, 2025

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157 Software

Popular Picks in Endpoint Detection and Response Software

Bitdefender GravityZone

Bitdefender GravityZone

$77.69 Per year

Cisco Secure Endpoint

Cisco Secure Endpoint

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Cortex XDR

Cortex XDR

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Cynet 360

Cynet 360

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List of Top Best Endpoint Detection and Response Software for Small Businesses

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ESET Endpoint Security is a robust solution for businesses seeking to fortify their cyber defenses. It stands out with its multi-layered security approach, combining traditional antivirus with advanced techniques like machine learning. This mix ensures effective defense against viruses, malware, and emerging threats. Unique to ESET is its low system footprint, ensuring security without compromisin... Read more about ESET Endpoint Security

Free Trial

Available

Pricing Type

$211 Per year

Location

Slovakia

Next-gen business AV to detect, prevent, and mitigate cyber threats effectively.

Bitdefender GravityZone is an advanced cybersecurity software suite developed to provide comprehensive protection for businesses of all sizes. Its key strength lies in its multi-layered defense mechanism, which includes antivirus, anti-malware, firewall, and ransomware protection. Notably, GravityZone employs machine learning and behavioral analysis to proactively detect and block new and evolving... Read more about Bitdefender GravityZone

Free Trial

NA

Pricing Type

$77.69 Per year

Location

Romania

Essential device and identity protection

McAfee AntiVirus Plus is a robust security software designed to protect your devices from various cyber threats. Its standout feature is the 'Real-Time Scanning,' which continuously monitors your system, instantly detecting and removing viruses and malware. The software supports multiple devices, ensuring your PCs, Macs, and smartphones are secure. With 'QuickClean,' it improves your device's perf... Read more about McAfee AntiVirus Plus

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Location

United States

Disrupt ransomware with industry-leading endpoint security on any platform.

Microsoft Defender for Endpoint is a comprehensive security solution tailored for enterprise environments. Its standout feature is 'Threat and Vulnerability Management', which proactively identifies and resolves security weaknesses. The software excels in 'Automated Investigation and Remediation', significantly reducing the workload on IT teams by addressing threats automatically. 'Endpoint Detect... Read more about Microsoft Defender for Endpoint

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NA

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Location

United States

Malwarebytes for Business is a top-tier cybersecurity solution tailored to protect businesses from a variety of digital threats. Its standout feature is its powerful anti-malware engine, which efficiently detects and removes malware, ransomware, and other malicious software that can jeopardize business operations. What sets it apart is its multi-layered defense approach, combining signature-based ... Read more about Malwarebytes for Business

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Location

United States

Aruba ClearPass is a leading network security software designed to provide comprehensive access control and visibility for enterprise environments. This powerful platform allows organizations to manage device authentication, enforce security policies, and monitor network activity seamlessly. With its robust policy engine, ClearPass ensures that only authorized devices can access the network, reduc... Read more about Aruba ClearPass

Free Trial

NA

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Location

United States

Cynet 360 is a comprehensive Endpoint Detection and Response (EDR) software designed to safeguard your organization's digital assets against sophisticated cyber threats. By integrating advanced threat intelligence, real-time monitoring, and automated response capabilities, Cynet 360 provides unparalleled protection for endpoints across your network. The software utilizes machine learning algorithm... Read more about Cynet 360

Free Trial

Available

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Location

United States

Secure Cloud Analytics is now part of Cisco XDR.

Cisco Secure Cloud Analytics is an advanced cybersecurity software designed to provide organizations with comprehensive visibility and protection against emerging threats in cloud environments. This powerful platform leverages machine learning and behavioral analysis to monitor network activity, detect anomalies, and respond to potential security incidents in real time. Cisco Secure Cloud Analytic... Read more about Cisco Secure Cloud Analytics

Free Trial

Available

Pricing Type

$600 Per feautre

Location

United States

Symantec Endpoint Detection and Response (EDR) is an industry-leading software solution designed to protect organizations from sophisticated cyber threats. Leveraging advanced analytics and machine learning, Symantec EDR provides comprehensive visibility into endpoint activities, enabling security teams to detect, investigate, and respond to potential threats in real time. The platform’s intuiti... Read more about Symantec Endpoint Detection and Response

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Available

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Location

United States

Cisco Secure Endpoint is an advanced network security software solution designed to provide comprehensive protection against threats across various endpoints. With its powerful detection and response capabilities, the software helps organizations identify and mitigate risks in real time. Cisco Secure Endpoint uses machine learning and behavioral analysis to recognize suspicious activities, enablin... Read more about Cisco Secure Endpoint

Free Trial

Available

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Location

United States

MVISION EDR is an advanced endpoint detection and response (EDR) software designed to enhance an organization’s cybersecurity posture by providing real-time threat detection and response. The software continuously monitors endpoints such as laptops, desktops, and servers for suspicious activity, and quickly responds to potential security threats. MVISION EDR uses machine learning and behavioral ... Read more about MVISION EDR

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NA

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Location

United States

Sophos Cloud Native Security is a cloud security software solution designed to protect businesses’ cloud environments from a wide range of cyber threats. The platform offers comprehensive security features that safeguard cloud applications, workloads, and infrastructure, including real-time threat detection, automated responses, and vulnerability management. Sophos uses machine learning and AI t... Read more about Sophos Cloud Native Security

Free Trial

NA

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Location

United States

VMware AppDefense is a sophisticated endpoint protection software designed to help organizations safeguard their applications and data from advanced threats. The platform provides tools for monitoring application behavior, detecting anomalies, and responding to security incidents in real-time. VMware AppDefense allows users to establish a security posture based on the expected behavior of applicat... Read more about VMware AppDefense

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NA

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Location

United States

IBM Security MDR is a sophisticated endpoint detection and response software designed to help organizations protect their networks and sensitive data from cyber threats. The platform provides comprehensive tools for threat detection, incident response, and continuous monitoring, ensuring that businesses can respond quickly to potential security incidents. IBM Security MDR utilizes advanced analyti... Read more about IBM Security MDR

Free Trial

NA

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Location

United States

Microsoft Defender for Office 365 is an advanced email security software that protects businesses from phishing attacks, malware, and other email-based threats. It provides real-time protection against malicious attachments, links, and impersonation attempts, reducing the risk of data breaches and compromised accounts. The platform integrates seamlessly with Microsoft Office 365, offering automate... Read more about Microsoft Defender for Office 365

Free Trial

NA

Pricing Type

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Location

United States

Network Detection and Response (NDR) is an advanced network monitoring software solution that provides real-time visibility into network activity and detects potential security threats before they can cause harm. NDR uses a combination of machine learning, behavioral analytics, and threat intelligence to monitor network traffic and identify suspicious patterns, unusual behavior, or unauthorized ac... Read more about Network Detection and Response

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NA

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Location

United States

Anomaly Detection Solution is a sophisticated website monitoring software that helps businesses identify unusual patterns and potential issues on their websites in real-time. By continuously tracking website traffic, user behavior, and system performance, the software can detect anomalies that may indicate security threats, technical failures, or usability problems. Anomaly Detection Solution uses... Read more about Apex One

Free Trial

Available

Pricing Type

Contact Vendor

Location

Japan

Cisco DNA is an advanced network security software platform that provides organizations with a comprehensive suite of tools to ensure the security, performance, and scalability of their networks. Built for enterprises, Cisco DNA offers intelligent network automation, analytics, and monitoring capabilities, enabling businesses to detect and mitigate security threats proactively. The software integr... Read more about Cisco DNA

Free Trial

NA

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Location

United States

Carbon Black EDR is a next-generation endpoint detection and response (EDR) cybersecurity software that helps organizations protect their networks, devices, and data from sophisticated cyber threats. It provides real-time threat detection, continuous monitoring, and advanced analytics to safeguard endpoints from malware, ransomware, phishing, and other types of attacks. Carbon Black EDR uses machi... Read more about Carbon Black EDR

Free Trial

NA

Pricing Type

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Location

United States

Carbon Black Cloud Workload is a robust vulnerability management software designed to protect workloads across physical, virtual, and cloud environments. This platform provides continuous monitoring and threat detection, enabling organizations to identify vulnerabilities and respond to potential threats proactively. With features such as real-time visibility into endpoint security, automated patch... Read more about Carbon Black Cloud Workload

Free Trial

NA

Pricing Type

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Location

United States

Apex One Endpoint Sensor is a robust endpoint detection and response (EDR) software designed to provide comprehensive protection against advanced threats targeting endpoints. This platform leverages advanced threat intelligence, behavioral analysis, and machine learning algorithms to detect, analyze, and respond to potential security incidents in real time. With features such as continuous monitor... Read more about Apex One Endpoint Sensor

Free Trial

NA

Pricing Type

Contact Vendor

Location

Japan

Microsoft Defender for Business is an advanced endpoint detection and response (EDR) software designed to protect small and medium-sized businesses (SMBs) from cyber threats. The platform provides comprehensive protection across devices, networks, and identities, with features such as real-time malware detection, ransomware protection, and threat intelligence. Microsoft Defender uses machine learn... Read more about Microsoft Defender for Business

Free Trial

Available

Pricing Type

$3 Per user

Location

United States

ESET Home Office Security Pack is an all-in-one computer security solution designed to protect home office environments from a wide range of online threats. With the rise of remote work, ESET offers powerful antivirus protection, firewall capabilities, and anti-phishing tools to safeguard devices and sensitive data. The software provides real-time protection against viruses, malware, ransomware, a... Read more about ESET Home Office Security Pack

Free Trial

NA

Pricing Type

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Location

United States

Superior protection with continuous threat hunting and monitoring via 24/7 managed detection & response service

ESET PROTECT MDR (Managed Detection and Response) is a sophisticated endpoint protection software that offers continuous monitoring, detection, and response capabilities to safeguard networks from potential threats. Designed for businesses of all sizes, ESET PROTECT MDR delivers advanced protection against malware, ransomware, and other cybersecurity risks by combining ESET's endpoint security sol... Read more about ESET PROTECT MDR

Free Trial

NA

Pricing Type

$211 Per year

Location

United States

Comodo is a leading endpoint protection software designed to safeguard businesses from cyber threats by providing robust security measures for all devices connected to the network. The software offers a comprehensive suite of features, including antivirus protection, firewall management, and real-time threat monitoring. Comodo’s endpoint protection includes proactive defense mechanisms, such as ... Read more about Comodo

Free Trial

NA

Pricing Type

Contact Vendor

Location

United States

Explore Today’s Featured List of Top Best Endpoint Detection and Response Software for Small Businesses

Enginsight

All-in-One Cybersecurity Attack & defense in one platform

Enginsight is an advanced network monitoring software designed to provide real-time visibility and control over your IT infrastructure. With its comprehensive dashboard, users can monitor network performance, track device status, and detect anomalies proactively. Enginsight supports a wide range of devices and applications, enabling seamless integration into existing IT environments. The software ... Read more about Enginsight

Free Trial

Available

Pricing Type

$8.91 Per month

Location

Germany

Secure Remote Worker is a powerful endpoint protection software designed to safeguard remote workers and their devices from cyber threats. With the increasing prevalence of remote work, businesses need robust security solutions to protect sensitive data, prevent data breaches, and secure devices from malicious attacks. Secure Remote Worker provides advanced protection features such as real-time th... Read more about Secure Remote Worker

Free Trial

NA

Pricing Type

Contact Vendor

Location

Ireland

ThinKiosk is a business continuity software designed to help organizations maintain operational resilience during unexpected disruptions. The platform allows IT teams to deliver a secure virtual desktop environment to employees, ensuring that critical applications and data remain accessible, even in remote work scenarios. ThinKiosk supports the conversion of existing devices into virtual endpoints... Read more about ThinKiosk

Free Trial

NA

Pricing Type

Contact Vendor

Location

Ireland

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